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i-FACTOR

i-FACTOR

 

i-FACTOR mechanism of action:

i-FACTOR Bone Graft is based on the biological activity of the synthetically derived 15-amino acid peptide found naturally in Type I human collagen. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. These cells have an affinity for and attach to the P-15 found in i-FACTOR Bone Graft in a similar way they would naturally with Type I collagen in bone.

i-FACTOR Bone Graft facilitates and expedites the ingrowth of bone by promoting the migration of mesenchymal stem cells and other progenitor cells from surrounding tissue.

The high affinity between cells and P-15 supports the physiological mechanism of action in which cells bind to the P-15 and “turn on” to perform their genetically programmed job of making bone.

The novel i-FACTOR Bone Graft “Attract, Attach, Activate” mechanism of action enhances the body’s natural bone healing process.

i-FACTOR Bone Graft is a peptide bone matrix (PBM) – a composite bone substitute consisting of a synthetic collagen fragment (P-15) bound to calcium phosphate particles. As an engineered product, P-15 quantity and viability remain consistent from lot to lot.

 

i-FACTOR Bone Graft comes in a Putty or as a FLEX with purified silk fibers. 

 

Handling procedure for i-FACTOR Putty:

  • When mixing Putty with autograft, ensure a thorough mix resulting in an even spread of granules throughout the structure of the graft material. We recommend a mix ratio of 30% Putty with 70% autograft (the maximum ratio is 50:50). The suggested ratio ensures that a physiologic quantity of natural growth factors is present for fast, safe, and effective fusion.
  • Mix Putty until no obvious clumping of the bone graft can be seen.
  • When used in conjunction with blood or bone marrow aspirate, leave the mixture to stand for 10 to 15 minutes to allow coagulation to occur.
  • Once in position, any loose surface granules should be removed by swabbing and suction prior to wound closure.

IMPORTANT: Do not irrigate once implanted.

 

Handling procedure for i-FACTOR FLEX FR:

  • Flex FR can be applied directly to the surgical site without the need to soak it with blood. However, adding some blood or BMA improves flexibility and the ability to mold the strip.
  • We recommend placing Flex FR into the surgical site once all hardware has been secured in position and immediately prior to closure.
  • Flex FR can be cut to fit into a cage.
  • When applied directly into a surgical site, we recommend that a layer of autograft be placed on top of the Flex FR.
  • Once in position, any loose surface granules should be removed by swabbing and suction prior to wound closure.

IMPORTANT: Do not irrigate once implanted.

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